An Ultrasound Experiment Tackles a Giant Problem in Brain Medicine
Health

An Ultrasound Experiment Tackles a Giant Problem in Brain Medicine

There is a problem with the recently approved Alzheimer’s drug, Aduhelm. It can remove some of the amyloid that forms brain plaques that are hallmarks of the disease. But most of the drug is wasted because it hits an obstacle, the blood-brain barrier, that protects the brain from toxins and infections but also prevents many drugs from entering.Researchers wondered if they could improve that grim result by trying something different: they would open the blood-brain barrier for a short time while they delivered the drug. Their experimental method was to use highly focused pulses of ultrasound along with tiny gas bubbles to pry the barrier open without destroying it.The investigators, at the Rockefeller Neuroscience Institute at West Virginia University, reported their results last week in Th...
Christian Pulisic interview: ‘I want to show the world what the U.S. can do’
Sports

Christian Pulisic interview: ‘I want to show the world what the U.S. can do’

Christian Pulisic is perched on a bar stool in the old clubhouse overlooking the first-team training pitch at Milanello, AC Milan’s training ground.He makes a hand gesture, one he didn’t need the past six months living in Italy to learn. Pulisic is talking about himself as one of the “older guys” on the USMNT and, as he does so, he is sure to put air quotes around it.Nearby is a portrait of Milan legend Paolo Maldini lifting a trophy, a player who retired in his forties. Pulisic isn’t that age yet. He turned 25 shortly after joining Milan from Chelsea in August. But as the United States get ready to host the Copa America as a guest competing nation this summer, the first newly-expanded 32-team Club World Cup the following year and then the biggest men’s World Cup finals yet, with 48 countr...
Do You Have ‘Bookshelf Wealth’?
Technology

Do You Have ‘Bookshelf Wealth’?

Breana Newton, a legal coordinator in Princeton, N.J., who posts regularly about books on TikTok, was one of the people who responded to Ms. Blalock’s video. “I am going to show you bookshelf wealth,” Ms. Newton, 33, says in a video of her own. “Ready?”She then gives viewers a brief tour of her home, showing books everywhere — on shelves, in overflow piles here and there, and strewed across the bed. Absent is the sense that the rooms have been staged, or that the books were bought with the consideration of how they would look on Instagram.In an interview, Ms. Newton said that she worried trends like bookshelf wealth encourage overconsumption. This year, she added, she is trying not to buy any new books.Another critic of the trend, Keila Tirado-Leist, said in a reaction video: “Who does it ...
A Fed Governor Reiterates That Rate Cuts Are Coming
Business

A Fed Governor Reiterates That Rate Cuts Are Coming

A prominent Federal Reserve official on Tuesday laid out a case for lowering interest rates methodically at some point this year as the economy comes into balance and inflation cools — although he acknowledged that the timing of those cuts remained uncertain.Christopher Waller, one of the Fed’s seven Washington-based officials and one of the 12 policymakers who get to vote at its meetings, said during a speech at the Brookings Institution on Tuesday that he saw a case for cutting interest rates in 2024.“The data we have received the last few months is allowing the committee to consider cutting the policy rate in 2024,” Mr. Waller said. While noting that risks of higher inflation remain, he said, “I am feeling more confident that the economy can continue along its current trajectory.”Mr. Wa...
Guatemala’s New President Is Sworn In, Despite Efforts to Stop Him
World

Guatemala’s New President Is Sworn In, Despite Efforts to Stop Him

Despite staunch resistance from his opponents in the government, the anticorruption crusader Bernardo Arévalo was inaugurated early Monday morning as Guatemala’s president, a turning point in a country where tensions have been simmering over widespread graft and impunity.His inauguration had been scheduled for Sunday, but members of Congress delayed it, and concerns persisted about whether it would happen at all. But after an international outcry and pressure from protesters, Mr. Arévalo was sworn in shortly after midnight, becoming Guatemala’s most progressive head of state since democracy was re-established in the 1980s.His rise to power — six months after his victory at the polls delivered a stunning rebuke to Guatemala’s conservative political establishment — amounts to a sea change in...
The Billionaires Spending a Fortune to Lure Scientists Away From Universities
Health

The Billionaires Spending a Fortune to Lure Scientists Away From Universities

In an unmarked laboratory stationed between the campuses of Harvard and the Massachusetts Institute of Technology, a splinter group of scientists is hunting for the next billion-dollar drug.The group, bankrolled with $500 million from some of the wealthiest families in American business, has created a stir in the world of academia by dangling seven-figure paydays to lure highly credentialed university professors to a for-profit bounty hunt. Its self-described goal: to avoid the blockages and paperwork that slow down the traditional paths of scientific research at universities and pharmaceutical companies, and discover scores of new drugs (at first, for cancer and brain disease) that can be produced and sold quickly.Braggadocio from start-ups is de rigueur, and plenty of ex-academics have s...
Naomi Osaka, The Comeback Interview: A tale of pregnancy, fear and a ballerina
Sports

Naomi Osaka, The Comeback Interview: A tale of pregnancy, fear and a ballerina

It was late September when Naomi Osaka, the four-time Grand Slam champion and transcendent star of her sport, finally got on the phone with her former coach to talk about her next comeback. Wim Fissette is a cerebral Belgian who thinks long and hard before taking on a player, even one with a resume like Osaka’s. He had one, very serious question.Is it going to be different this time?There was then another conversation, with Florian Zitzelsberger, a 34-year-old German who is one of the most respected strength and conditioning coaches in the world. Zitzelsberger had worked with Osaka before, too. He asked her the same question, and another important one, too. Why?World-class tennis players worth hundreds of millions of dollars are not used to pushback like this. They get what they ask for, w...
California Has Dealt a Blow to Renewable Energy, Some Businesses Say
Technology

California Has Dealt a Blow to Renewable Energy, Some Businesses Say

California has long championed renewable energy, but a change in the state’s policies last year has led to a sharp decline in the installation of residential rooftop solar in the state.Thousands of companies — including installers, manufacturers and distributors — are reeling from the new policy, which took effect in April and greatly reduced incentives that had encouraged homeowners to install solar panels. Since the change, sales of rooftop solar installations in California dropped as much as 85 percent in some months of 2023 from a year earlier, according to a report by Ohm Analytics, a research firm that tracks the solar marketplace. Industry groups project that installations in the state will drop more than 40 percent this year and continue to decline through 2028.“The solar installat...
At Sam’s Club, a Human Will No Longer Check Your Receipt at the Door
Business

At Sam’s Club, a Human Will No Longer Check Your Receipt at the Door

Buying things in bulk at wholesale retailers can be an all-day affair. Sam’s Club, the store chain owned by Walmart, is trying to make that time shorter: by using artificial intelligence to scan shoppers’ carts so they no longer have to show a receipt at the exit upon checking out.“Eliminating even the few seconds it takes to scan a receipt at the exit door is well worth it,” Megan Crozier, an executive vice president at Walmart, announced onstage this week at the company’s presentation for the Consumer Electronics Show in Las Vegas.It has long been common practice at stores where bulk items are sold — like Costco, Sam’s Club and BJ’s Wholesale Club — for store employees to check customer receipts at the exit. But this has also led to accusations of racial bias, with some customers saying ...
Whisky From Wales? Believe It, Say the Welsh.
World

Whisky From Wales? Believe It, Say the Welsh.

It is famed for a love of singing and a passion for rugby. It has a distinctive Celtic language and is the birthplace of the poet Dylan Thomas. But few would claim that Wales, a nation of three million people outnumbered by sheep, is well known for whiskey, or whisky, as it is known in Wales.Yet the country has played its part in distilling history — a Welshman is considered one of the founding fathers of bourbon — and a recent revival of whisky production has prompted new rules governing which liquor can call itself Welsh.That was how the problems began in Abergwyngregyn (pronounced ABER-gwin-gregin), in the shadow of the ice-capped Snowdonia mountain range, where Aber Falls single-malt whisky is produced in a distillery filled with the strong malty aroma of barley.Made with exclusively W...